ANKK1, TTC12, and NCAM1 Polymorphisms and Heroin Dependence
نویسندگان
چکیده
منابع مشابه
ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure.
CONTEXT The genetic contribution to liability for opioid dependence is well established; identification of the responsible genes has proved challenging. OBJECTIVE To examine association of 1430 candidate gene single-nucleotide polymorphisms (SNPs) with heroin dependence, reporting here only the 71 SNPs in the chromosome 11 gene cluster (NCAM1, TTC12, ANKK1, DRD2) that include the strongest ob...
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There have been many conflicting reports concerning the association of the DRD2 locus with alcohol dependence (AD). To investigate whether these findings could be reconciled by considering the genomic region of DRD2 in greater detail, we conducted two separate association studies of AD in 1220 European-American subjects using family-based (488 subjects) and case-control (318 cases and 414 contr...
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Genetic studies have long suggested the important role of the DRD2 gene in psychiatric disorders and behavior. Further research has shown a conjoined effect of genes in the Chr11q22-23 region, which includes the NCAM1, TTC12, ANKK1 and DRD2 genes, or NTAD cluster. Despite a growing need to unravel the role of this cluster, few studies have taken into account interspecies and evolutionary approa...
متن کاملHaplotype analysis of DRD2 and ANKK1 gene polymorphisms in alcohol dependence
Jolanta Kucharska-Mazur1, Anna Grzywacz1, Justyna PełkaWysiecka1, Agnieszka samochowiec1,2, Hans Rommelspacher3, Jerzy samochowiec1: 1 Department of Psychiatry, Pomeranian Medical University, 26 Broniewskiego Str., 71-460 Szczecin, Poland. 2 Department of Clinical Psychology and Psychoprophylaxis, Institute of Psychology, University of Szczecin, 69 Krakowska Str., 71-004 Szczecin, Poland. 3 Dep...
متن کاملOpioid Receptors Gene Polymorphism and Heroin Dependence in Iran
Introduction: Genes often have multiple polymorphisms that interact with each other and the environment in different individuals. Variability in the opioid receptors can influence opiate withdrawal and dependence. In humans, A118G Single Nucleotide Polymorphisms (SNP) on μ-Opioid Receptor (MOR), 36 G>T in κ-Opioid Receptor (KOR), and T921C in the δ-Opioid Receptor (DOR) have been...
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ژورنال
عنوان ژورنال: JAMA Psychiatry
سال: 2013
ISSN: 2168-622X
DOI: 10.1001/jamapsychiatry.2013.282